Development of a web tool to calculate the cumulative dose of glucocorticoids

نویسندگان

چکیده

Glucocorticoids are associated with serious side effects related to dosing and time of use. Unfortunately, there is no standard method for determining glucocorticoid exposure, especially in patients undergoing long-term treatment. The aim this work was create a free easy-to-use web application calculate, systematic way, the total cumulative dose corticosteroids. calculated as sum all periods treatment different doses corticosteroids, expressed equivalent prednisone mg. Glucocorticoid during which available information missing or incomplete estimated by assumptions. A simulation exercise using patterns steroid use polymyalgia rheumatica, giant cell arteritis showed that even when period reached 50% time, accuracy calculator had mean absolute percentage error (MAPE) < 7%. This tool simplifies standardizes glucocorticoids calculation, thereby minimizing bias assessment dose. Los glucocorticoides se asocian con efectos secundarios graves, relacionados dosis y tiempo de uso. Desafortunadamente, existe un método estándar disponible para determinar el nivel exposición en tratamientos prolongados. Crear una aplicación gratuita fácil usar calcular, forma sistematizada, la acumulada glucocorticoides. La calcula como suma todos los períodos tratamiento diferentes dosis, expresa equivalente prednisona durante que información está o incompleta estima mediante asunciones sistematizadas. Un ejercicio simulación utilizando patrones uso esteroides polimialgia reumática células gigantes demostró que, incluso cuando período ausencia alcanzaba del tiempo, precisión calculadora tenía porcentaje medio absoluto Esta herramienta simplifica estandariza cálculo acumulativa glucocorticoides, minimizando sesgo cálculo.

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ژورنال

عنوان ژورنال: Reumatología Clínica

سال: 2023

ISSN: ['2173-5743']

DOI: https://doi.org/10.1016/j.reuma.2022.04.004